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Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2); German version EN 16418:2014

Standard [CURRENT]

DIN EN 16418:2014-07

Paper and board - Determination of the cytotoxicity of aqueous extracts using a metabolically competent hepatoma cell line (HepG2); German version EN 16418:2014

German title
Papier und Pappe - Bestimmung der Zytotoxizität von wässrigen Extrakten unter Verwendung einer metabolisch kompetenten Hepatom-Zelllinie (HepG2); Deutsche Fassung EN 16418:2014
Publication date
2014-07
Original language
German
Pages
24

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Publication date
2014-07
Original language
German
Pages
24
DOI
https://dx.doi.org/10.31030/2066259

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Overview

This document (EN 16418:2014) has been prepared by Technical Committee CEN/TC 172 "Pulp, paper and board", the secretariat of which is held by DIN (Germany). This European Standard specifies a test method for the laboratory assessment of the potential cytotoxic effect of paper and board intended to come into contact with foodstuffs using specifically the HepG2 cell line. Compared to the EN 15845, HepG2 cells are more representative of a human oral exposure to xenobiotics, due to the presence in the cells of phase I, II and III enzymes of the metabolism.

Content

ICS

85.060

DOI

https://dx.doi.org/10.31030/2066259

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